|Year : 2020 | Volume
| Issue : 1 | Page : 112-118
Evaluation of pancreaticogastrostomy using pancreas-transfixing sutures versus a single purse-string seromascular nonpancreatic suture in Whipple operation: a prospective randomized-controlled trial
Hamada Fathy, Ahmed H Mohammed, Mohamed Gamal Sayed, Haidi Abd-Elzaher Mohamed, Mohammed Faisal
Surgical Oncology Unit, Department of Surgery, Faculty of Medicine, Ismailia, Suez Canal University Hospital, Egypt
|Date of Submission||08-Jul-2019|
|Date of Decision||18-Jul-2019|
|Date of Acceptance||17-Sep-2019|
|Date of Web Publication||14-Feb-2020|
MD of Surgery Mohammed Faisal
Surgical Oncology Unit, Department of Surgery, Faculty of Medicine, Suez Canal University, Circular Road, Ismailia 411522
Source of Support: None, Conflict of Interest: None
Background Pancreatic fistula (PF) remains a persistent problem after pancreaticoduodenectomy (PD). The existence of soft, nonfibrotic pancreatic tissue is one of the critical risks for pancreatic leakage. Our aim was to compare continuous single purse-string sutures and transfixing suture for performing pancreaticogastrostomy to the pancreatic stump in terms of the outcome and the rate of postoperative complications for PD.
Patients and methods Our study included 40 patients who were diagnosed with different stages of pancreatic cancer and admitted to the general surgery department of Suez Canal University Hospital. These patients were enrolled in the study and underwent PD.
Results The rate of postoperative PF rate was lower when using single purse-string suture for performing pancreaticogastrostomy than when using the transfixing suture (0 vs. 15%, respectively).
Conclusion We found a link between the occurrence of postoperative PF and possible risk factors such as soft pancreas and small Wirsung duct diameter.
Keywords: fistula, pancreaticogastrostomy, purse-string, Whipple
|How to cite this article:|
Fathy H, Mohammed AH, Sayed MG, Mohamed HA, Faisal M. Evaluation of pancreaticogastrostomy using pancreas-transfixing sutures versus a single purse-string seromascular nonpancreatic suture in Whipple operation: a prospective randomized-controlled trial. Egypt J Surg 2020;39:112-8
|How to cite this URL:|
Fathy H, Mohammed AH, Sayed MG, Mohamed HA, Faisal M. Evaluation of pancreaticogastrostomy using pancreas-transfixing sutures versus a single purse-string seromascular nonpancreatic suture in Whipple operation: a prospective randomized-controlled trial. Egypt J Surg [serial online] 2020 [cited 2020 Feb 24];39:112-8. Available from: http://www.ejs.eg.net/text.asp?2020/39/1/112/278269
| Introduction|| |
Pancreatic carcinoma is the 11th most common carcinoma type and is the fourth leading cause of death worldwide. It was found that in 2016, 53 670 Americans were diagnosed with pancreatic cancer and 30 390 died from the disease . Nationally, the incidence of pancreatic malignant tumors in Egypt reached 5.6% in 2014 .
Most resectable malignant tumors are those of the pancreatic head and the procedure of choice is pancreaticoduodenectomy (PD) . Leakage after pancreatic cancer surgery remains a frequent and crucial complication after both standard PD and pylorus-preserving PD. Pancreatic fistula (PF) is, in certain cases, accompanied by a few other possibly life-threatening consequences, as well as massive hemorrhage of the eroded vessels and peritonitis . Because of this, surgeons are providing more care and paying more attention toward finding the appropriate technique of pancreatic reconstruction . Traditionally, pancreatojejunostomy (PJ) was considered almost certainly the most widespread method of reconstruction, accompanied by several alternatives, such as telescoping, single layer, and double-layer end-to-end techniques .
The utilization of the stomach as an easy way for reinstating pancreatic continuity has additionally been defined and analyzed as a substitute for jejunal anastomosis in either observational studies or randomized-controlled trials (RCTs). It has actually been advocated that adverse effects after reconstruction with Pancreaticogastrostomy (PG) can certainly be controlled conservatively more frequently than after pancreatojejunostomy reconstruction; also, the anastomosis in PG can be more readily conceived a result of the proximity of the stomach to the pancreas . The posterior wall of the stomach is thick and highly vascularized compared with the jejunum .
| Patients and methods|| |
After obtaining approval from our ethics committee, this prospective randomized-controlled case-series study was carried out in the General Surgery Department, Surgical Oncology Unit, Suez Canal University Hospital, on 40 patients who were admitted to the General Surgery Department of Suez Canal University Hospital after they were diagnosed with resectable pancreatic cancer. All patients in our study underwent PD. PG was performed using two different techniques: transfixing pancreatic suture in the first 20 patients (group 1) and single purse-string seromuscular nonpancreatic suture in the next 20 patients (group 2). After obtaining an informed written consent from all the patients, they were subjected to the following: a thorough assessment of history, and general and local examinations, and were referred for abdominal ultrasonography and abdominal computed tomographic scan with pancreatic protocol. The patients who showed radiological evidence of pancreatic cancer and fulfilled the inclusion criteria and were not included in the exclusion criteria were included in the study. Preoperative investigations were performed for all patients including full blood count, random blood sugar, coagulation profile, liver enzymes, serum creatinine, CA 19-9, and CEA. The eligible patients were admitted to the hospital and were prepared for PD with PG.
A bilateral subcostal incision with upper midline extension was performed. The PD was performed according to our institutional standardized technique as described elsewhere. Transection of the pancreatic distal stump was generally performed at the pancreatic neck or body, depending on the tumors’ location, by a blade and a frozen section was performed at this level to detect the presence of tumor invasion. Then, the distal pancreatic stump was transfixed at its cranial and caudal edge with two 3-0 PDS stay sutures (Ethicon, Inc., NJ, USA).
In the first group, we performed PG as follows:
A 2-cm-long seromuscular incision was made in the posterior wall of the stomach, followed by invagination of the pancreatic stump into the stomach and an end-to-side pancreaticogastric anastomosis was performed in a single layer of sutures consisting of 3-0 PDS placed by a curved 35-mm-long needle from the posterior inferior wall to the superior wall of the stomach, and then passed from the anterior to the posterior surface of the pancreas. The sutures on the stomach were placed widely so that the pancreatic stump could be embedded into the wall of the stomach at the seromuscular incision. The sutures on the pancreas were placed 1 cm away from the cut edge. Six to eight sutures were generally used, although the number depended on the size of the stump of the pancreatic remnant ([Figure 1]).
|Figure 1 First technique using transfixing suture. Showed the 4 steps : (A, B,C,D) of the techniques which illustrated in detail in methods part.|
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In the second group, we performed PG as follows:
A transversal full-thickness incision was made on the posterior gastric wall with a length of 2 cm at the most to ensure tight adherence to the posterior wall of the stomach and the pancreatic stump after completion of the anastomosis. The relevant place for the incision was selected so that the pancreatic stump could enter the opening without tension. A continuous seromuscular circular suture (3-0 PDS) was placed around the gastric incision 1 cm away from the cut edge. The pancreatic remnant was pulled with slide tension on the holding sutures through the hole in the posterior gastric wall into the stomach. Ideally, the pancreatic remnant should protrude from the posterior gastric wall by 2 cm. Then, the seromuscular continuous circular suture was tied to the lowest part of the pancreatic stump ([Figure 2]). This ensured submucosal hemostasis and water-tight anastomosis.
|Figure 2 Second technique using single purse-string. Showed a real picture (D) of the ended technique.|
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After the completion of the anastomosis in both groups, the permeability of the main pancreatic duct was checked with a catheter probe (intravenous catheter, 20 G). Two abdominal drains were placed close to the PG through the foramen of Winslow (right drain) and the lesser sac (left drain). Drain output was checked daily for amylase levels until the seventh postoperative day. Drains were then removed in the absence of a PF according to the International Study Group for Pancreatic Fistula definition.
The collected data were coded and entered into the statistical package of social sciences (version 21.00; SPSS Inc., Chicago, IL, USA) program for statistical analysis. Descriptive data were managed according to its type: mean, SD, and range, whereas qualitative data were summarized as frequencies. For the analytical data, the χ2 test and the Fisher test were used to detect the difference between qualitative data, whereas the Student t test was used to detect differences between continuous data.
| Results|| |
Forty pancreatic cancer patients who were undergoing the Whipple operation were enrolled in the study; 20 were candidates for pancreas-transfixing suture (group 1) and 20 for purse-string seromuscular nonpancreatic suture (group 2) for performing PG. The difference between the two groups in terms of age, sex, and history of diabetes was not statistically significant as shown in [Table 1].
In terms of tumor location, 85% of the patients in group 1 and 95% of the patients in group 2 had tumors that were located in the head of the pancreas and the rest were located in the neck of the pancreas. In terms of tumor size, 45% of the tumors in group 1 and 40% of the tumors in group 2 were less than 3 cm. More than half of the patients in each group (55% of group 1 vs. 60% of group 2) had high-grade tumors, followed by moderate-grade tumors (45 and 30% in the two groups, respectively), and only minority of group 2 (10%) had low-grade tumors as shown in [Table 2].
Pancreatic texture was soft in 45% of the patients of group 1 and 60% of the patients in group 2. In terms of Wirsung duct diameter, it was less than or equal to 4 cm in 70% of the patients in group 1 and in 75% of the patients in group 2. In terms of the operative blood loss, 90% of the patients in group 1 versus 75% of the patients in group 2 lost less than or equal to 1500 ml and 10% of the patients in group 1 and 25% of the patients in group 2 lost more than 1500 ml of blood intraoperatively. The mean duration of the operation was 5.5±0.8 in group 1 compared with 5±0.6 in group 2 and there was a statistically significant difference as shown in [Table 3].
|Table 3 Pancreatic texture, Wirsung duct diameter, and duration of operation among the two groups studied|
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The duration of PG was higher among the patients in group 1 compared with the patients in group 2 (34±7.7 vs. 28.6±7, respectively), and the difference was statistically significant as shown in [Figure 3].
Postoperative complications were assessed in the two groups. [Table 4] shows that three (15%) patients in group 1 developed postoperative pancreatic fistula (POPF); two (10%) of them were grade A and were treated conservatively, whereas one (5%) was grade B and was treated by ultrasound-guided drainage and antibiotics. No patients in group 2 developed POPF. The rest of the postoperative complications are shown in [Table 5].
| Discussion|| |
PD is the standard procedure for the treatment of patients with pancreatic cancer and other periampullary diseases. However, postoperative complications of PD are still common . POPF and delayed gastric emptying are the principal complications of PD and may sometimes be fatal. Other complications such as postoperative wound infections, intraabdominal fluid collection, and hemorrhage are also common after PD . In clinical practice, various techniques or modifications of PG are carried out to minimize the complications of PD.
In 45% of group 1 and 40% of group 2 patients; the mean tumor size by computed tomography was less than 3.5 cm in maximum diameter, whereas in the rest of the patients, the tumor size was larger than 3.5 cm. These are closely related to Zhan et al. , who found that the mean tumor size was 4.6±2.2 cm (range, 0.5–14 cm), with 12 (16%) patients having tumors smaller than 3 cm, whereas in 70 (84%) patients, tumors were larger than 3 cm. This may be justified in the light of late presentation or aggressiveness of tumor behavior. Capello et.al.  found that tumor size less than 3 cm is an independent predictive factor for resectability.
In the present study, 17 (85%) patients of group 1 and 19 (95%) patients of group 2 had tumors that were located at the head of the pancreas, whereas the rest of the tumors were located at the body and the tail of the pancreas. These findings are in agreement with the data of Ryan et al. , who reported that ∼75% of all pancreatic carcinomas occur within the head or neck of the pancreas, 15–20% occur in the body of the pancreas, and 5–10% occur in the tail.
Intraoperatively, pancreatic parenchyma was considered hard in 11 (55%) patients of group 1 and eight (40%) patients of group 2. Like group 1, Hiroaki et al. , who performed PG using mattress sutures, found that 10 (52.9%) out of 17 of his patients had a hard pancreas. This may be explained by the fact that both studies had the same inclusion criteria. Similarly, Wang et al. , who used a single purse-string duct to mucosa PG, found that 40% of their studied patients had firm or fibrosed pancreatic texture close to the group 2 results.
In our study, 70% of the patients of group 1 and 75% of the patients of group 2 were found to have Wirsung duct diameter less than 3 mm. Similar results have been obtained by Wang et al. , who found that 45 (61.5%) patients had pancreatic duct diameter less than 3 mm. Also, Addeo et al.  found that the mean size of the pancreatic duct was 4±2 mm (median, 3 mm; range, 2–9 mm), with 28 out of 40 patients having a Wirsung diameter less than 3 mm. The size of the pancreatic duct has been implicated as a major predictor of fistula. This is particularly important because when a small nondilated pancreatic duct, typically defined as less than or equal to 3 mm in diameter, is found, patients are more likely to be predisposed to PF compared with patients with dilated ducts.
The mean time for PG anastomosis in the trans-pancreatic suture group, from the incision of the posterior gastric wall to completion of the inner layer, was 34±7.7 min. This is similar to the results reported by Jeong et al. , who took a mean of 32±7 min for the completion of PG anastomosis, and also to Hiroaki et al. , who used trans-pancreatic mattress sutures and found that the mean duration for the anastomosis was 36±6 min.
The mean time for PG anastomosis in the purse-string suture group (from the incision of the posterior gastric wall till ligation of the inner layer) was 25.6±7 min; this is close to Addeo et al. , who found that the median time for the PG anastomosis was 21 min (range, 18–30 min). Daniel et al. , who performed PG using a single continuous circular suture, reported a mean operative time for PG of 22±9 min and a median of 9 min. However, Feng et al.  reported a much shorter time of 12 min for the PG (range, 8–24 min). The difference between these results and ours may be attributed to the fact that the former study was carried out in a high-volume center.
In group 1, three (15%) patients had POPF; two (10%) of them were grade A and one (5%) was grade B. The two patients with type A fistula had spontaneous regression of elevated drain amylase levels by POD seven, and all drains were eventually removed by POD 10. One patient with a type B PF underwent ultrasound-guided drainage of a peripancreatic collection and was managed on an outpatient basis by leaving the operative drain until POD 20. Similar results were obtained by Aranha et al. , who found that 15% (20 patients) of the patients developed grade A POPF among the 152 cases studied. They used pancreas-transfixing suture for the PG anastomosis as we did. Jeong et al.  found relatively similar results; they found that among the 63 patients studied, 22% (13 patients) had grade A POPF and 3% (two patients) had grade B POPF.In our work, none of the patients in group 2 developed POPF. Similar results were obtained by Addeo et al. , who used a similar technique for the PG anastomosis and found that the overall PF rate was 4% (two out of 50 patients) according to the International Study Group for Pancreatic Fistula definition. In the two patients, one PF was graded as type A and the second as type B, and both were treated conservatively. There were no type C PFs. All fistulas occurred in patients with a soft pancreatic parenchyma. Meanwhile, Feng et al. , who adopted a similar PG technique, found that POPF was encountered in two (1.7%) patients. According to the international clinical grading system, one patient had grade A POPF. This case was treated conservatively and fed orally without any additional intervention. One patient had grade B POPF and underwent an interventional drainage procedure with B-mode ultrasonic guidance.
In our study, it was found that postoperative biliary leakage occurred only in one (5%) patient in group 1, whereas none was encountered in group 2 and intestinal anastomotic leakage was found only in group 2 in 5% (1 patient) of the patients, but did not occur in group 1. Similarly, Han et al.  reported biliary leak in one (1%) patient, with no reported enteric leak following PD. Aranha et al.  also detected 1% (one patient) biliary leak with 0% intestinal anastomotic leakage.
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| References|| |
Ibrahim AS, Khaled HM, Mikhail NN, Baraka H, Kamel H. Cancer incidence in Egypt: results of the National Population-Based Cancer Registry Program. J Cancer Epidemiol 2014; 2014:1–18.
Winter JM, Cameron JL, Campbell KD, Campbell KA, Chang D, Riall TS et al.
Periampullary and pancreatic incidentaloma: a single-institution experience with an increasingly common diagnosis. Ann Surg 2006; 243:673–683.
Reid-Lombardo KM, Farnell MB, Crippa S, Barnett M, Maupin G, Bassi C et al.
Pancreatic anastomotic leakage after pancreaticoduodenectomy in 1,507 patients: a report from the pancreatic anastomotic leak study group. J Gastrointest Surg Off J Soc Surg Aliment Tract 2007; 11:1451–8. discussion 1459.
Conzo G, Gambardella C, Tartaglia E, Sciascia V, Mauriello C, Napolitano S et al.
Pancreatic fistula following pancreatoduodenectomy. Evaluation of different surgical approaches in the management of pancreatic stump. Literature review. Int J Surg 2015; 21:S4–S9.
Figueras J, Sabater L, Planellas P, Muñoz-Forner E, Lopez-Ben S, Falgueras L et al.
Randomized clinical trial of pancreaticogastrostomy versus pancreaticojejunostomy on the rate and severity of pancreatic fistula after pancreaticoduodenectomy. Br J Surg 2013; 100:1597–1605.
Bartsch DK, Langer P, Kanngießer V, Fendrich V, Dietzel K. A simple and safe anastomosis for pancreatogastrostomy using one binding purse-string and two transfixing mattress sutures. Int J Surg Oncol 2012; 2012:1–7.
Liu F, Chen J, Geng W, Xie S, Zhao Y, Yu L et al.
Pancreaticogastrostomy is associated with significantly less pancreatic fistula than pancreaticojejunostomy reconstruction after pancreaticoduodenectomy: a meta‐analysis of seven randomized controlled trials. HPB 2015; 17:123–130.
Levenick JM, Sutton JE, Smith KD, Gordon SR, Suriawinata A, Gardner TB. Pancreaticoduodenectomy for the treatment of groove pancreatitis. Dig Dis Sci 2012; 57:1954–1958.
Suzuki S, Kaji S, Koike N, Harada N, Suzuki M. Pancreaticoduodenectomy can be safely performed in the elderly. Surg Today 2013; 43:620–624.
Zhan H, Xu J, Wang L, Zhang G, Hu S. Lymph node ratio is an independent prognostic factor for patients after resection of pancreatic cancer. World J Surg Oncol [Internet]. 2015; 13. Available from: http://www.wjso.com/content/13/1/105
[cited 2018 Mar 11].
Capello M, Bantis LE, Scelo G, Zhao Y, Li P, Dhillon DS et al.
Sequential validation of blood-based protein biomarker candidates for early-stage pancreatic cancer. J Natl Cancer Inst 2017; 109.
Ryan D, Hong T, Bardeesy N. Pancreatic adeno-carcinoma (PDF). N Engl J Med 2014; 371:1039–1049.
Wang X-A, Wu X-S, Cai Y, Jin H-C, Shen W-M, Liu Y-B et al.
Single purse-string duct to mucosa pancreatico-gastrostomy: a safe, easy, and useful technique after pancreaticoduodenectomy. J Am Coll Surg 2015; 220:e41–48.
Addeo P, Rosso E, Fuchshuber P, Oussoultzoglou E, Souche R, Nobili C et al.
Double purse-string telescoped pancreatico-gastrostomy: an expedient, safe, and easy technique. Am Coll Surg 2013; 216:e27–33.
Lee JY, Kim EY, Lee JS, Lee SH, Na GH, Hong TH et al.
A novel pancreaticogastrostomy method using only two transpancreatic sutures: early postoperative surgical results compared with conventional pancreaticojejunostomy. Ann Surg Treat Res 2015; 88:299–305.
Kostov D, Kobakov G, Yankov D. Pancreatico-gastrostomy with one continuous seromuscular circular suture. Int J Surg Med 2015; 1:2.
Zhu F, Wang M, Wang X, Tian R, Shi C, Xu M et al.
Modified technique of pancreatico-gastrostomy for soft pancreas with two continuous hemstitch sutures: A Single-Center Prospective Study. J Gastrointest Surg 2013; 17:1306–1311.
Aranha GV, Hodul PJ, Creech S, Jacobs W. Zero mortality after 152 consecutive pancreaticoduodenectomies with pancreaticogastrostomy. J Am Coll Surg 2009; 197:223–231; discussion 231–232.
Qin H, Luo L, Zhu Z, Huang J. Pancreaticogastrostomy has advantages over pancreaticojejunostomy on pancreatic fistula after pancreaticoduodenectomy. A meta-analysis of randomized controlled trials. Int J Surg Lond Engl 2016; 36:18–24.
[Figure 1], [Figure 2], [Figure 3]
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5]