Home Current issue Ahead of print Search About us Editorial board Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 37  |  Issue : 1  |  Page : 116-121

Living donor liver transplantation for hepatocellular carcinoma: Milan criteria versus University of California San Francisco


1 Department of General Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Ahmed Khalil
Department of Surgery, Ain Shams University, Abassia, Cairo, 11471
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejs.ejs_132_17

Rights and Permissions

Introduction Hepatocellular carcinoma (HCC) is the most common primary liver cancer and most patients with HCC also suffer from coexisting cirrhosis. HCC recurrence is a major concern after liver transplant. The Milan criteria was accepted after a good 5 years survival but was criticized for being so restricted and this criticism promoted the appearance of more expanded criteria like the University of California San Francisco (UCSF). Our study compares the results of both Milan and UCSF criteria and the risk factors for recurrence. Patients and methods This study included 60 patients had living donor liver transplantation for HCC between January 2011 and December 2016 in Ain Shams Center for Organ Transplantation.They were divided into two groups. Group A: transplanted within the Milan criteria; and group B: transplanted while beyond Milan but within the UCSF criteria. Both groups are compared as regards the recurrence, survival, and risk factors for recurrence. Results There is no statistically significant difference between the two groups as regards the survival and recurrence. The 1 and 3 years survival were 86.5 and 71.9% for the Milan group and 81.7 and 61.4% in the group of patients beyond Milan (statistically nonsignificant, P=0.348). Seven (15.1%) patients from the Milan group had recurrence while in the beyond Milan group four (28.6%) patients had recurrence (statistically nonsignificant, P=0.258). There were no statistically significant difference in microvascular invasion (P=0.388), tumor grade (P=0.207), and α-fetoprotein (P=0.112) between both groups. Conclusion Milan criteria can be safely expanded to UCSF with comparable results if responding well to downstaging and with low α-fetoprotein.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed175    
    Printed8    
    Emailed0    
    PDF Downloaded30    
    Comments [Add]    

Recommend this journal