|Year : 2016 | Volume
| Issue : 3 | Page : 155-161
Doppler-guided hemorrhoidal artery ligation with recto-anal repair versus Milligan Morgan hemorrhoidectomy for grade IV hemorrhoids
Tarek Mohammad Sherif1, Abd Elrahman Amin Sarhan2
1 Department of General Surgery, Al Ahli Hospital, Doha, Qatar
2 Department of General Surgery, Al Amiri Hospital, Kuwait City, Kuwait
|Date of Submission||26-Dec-2015|
|Date of Acceptance||06-Feb-2016|
|Date of Web Publication||30-Aug-2016|
Tarek Mohammad Sherif
Department of Surgery, Faculty of Medicine, Sharkia, Zagazig University, Egypt
Source of Support: None, Conflict of Interest: None
Milligan Morgan (MM) hemorrhoidectomy is associated with significant postoperative pain and late return to daily activities. Doppler-guided hemorrhoid artery ligation with recto-anal repair (DG-HAL with RAR) is a minimal-invasive surgical treatment for hemorrhoids that has been used as an alternative method in order to reduce these inconveniences.
The aim of this study was to compare the results of the two procedures in the management of grade IV hemorrhoids.
This prospective, randomized, clinical study was carried out between June 2011 and June 2015. It included 126 patients with grade IV hemorrhoids, who were divided into two equal groups: group A, in which 63 patients were operated for DG-HAL with RAR; and group B, in which 63 patients were operated for MM hemorrhoidectomy. Patients were evaluated preoperatively and postoperatively at 1 week, 1 month, 6 months, and 1 year. The follow-up period was 1 year.
The mean age was higher in group A patients (P = 0.003). The operative time was significantly longer in group A (P > 0.001). The first defecation occurred sooner in group A (P = 0.006) than in group B. The mean hospital stay was significantly shorter in group A (P > 0.001). Moreover, the return to work was achieved significantly earlier in group A (P > 0.001). The postoperative pain score (visual analog scale) was significantly less in group A patients, especially during defecation (P > 0.001). The postoperative consumption of class II and III analgesics was significantly less in group A than in group B (P > 0.005). After 1 year of follow-up, there were no significant differences between the two groups as regards postoperative complications, recurrent prolapse, anorectal function, and fecal continence.
DG-HAL with RAR is an effective minimal-invasive procedure with results comparable to MM hemorrhoidectomy for the treatment of grade IV hemorrhoids with fewer complications, less postoperative pain, shorter hospital stay, and earlier return to work.
Keywords: hemorrhoidal artery ligation, hemorrhoidectomy, hemorrhoids, recto-anal repair
|How to cite this article:|
Sherif TM, Sarhan AA. Doppler-guided hemorrhoidal artery ligation with recto-anal repair versus Milligan Morgan hemorrhoidectomy for grade IV hemorrhoids. Egypt J Surg 2016;35:155-61
|How to cite this URL:|
Sherif TM, Sarhan AA. Doppler-guided hemorrhoidal artery ligation with recto-anal repair versus Milligan Morgan hemorrhoidectomy for grade IV hemorrhoids. Egypt J Surg [serial online] 2016 [cited 2018 Aug 21];35:155-61. Available from: http://www.ejs.eg.net/text.asp?2016/35/3/155/189431
| Introduction|| |
Hemorrhoids are highly vascularized tissues located in the submucosa of the anal canal that help in maintaining the fecal continence . Hemorrhoid disease can be defined as the symptomatic enlargement and protrusion of normal anal cushions . Milligan Morgan (MM) hemorrhoidectomy is considered the gold standard for the surgical treatment of hemorrhoids . However, this procedure is associated with significant postoperative complications including pain, sepsis, anal stenosis, bleeding, and incontinence . In an effort to decrease postoperative pain, two new techniques have been proposed in the last two decades: stapled hemorrhoidopexy and Doppler-guided hemorrhoidal artery ligation (DG-HAL). Both techniques result in less postoperative pain, a shorter hospital stay, and greater patient satisfaction ,,,,,,. Numerous case reports have exposed some of the potential risks with stapled hemorrhoidopexy, including bleeding, large bowel obstruction, retroperitoneal sepsis, recto-vaginal fistula, and rectal perforation ,. DG-HAL was first described by Morinaga et al. . It has been shown to be safe and effective in the treatment of hemorrhoids and to be associated with a small learning curve . From the time of its introduction, numerous devices have been developed. The most recent modification of selective hemorrhoidal artery ligation method, the recto-anal repair (RAR), combines selective DG-HAL with plication of the prolapsed rectal mucosa, using the specially designed proctoscope (A.M.I. Trilogy) [Figure 1]. The aim of this procedure is to reduce the enlarged hemorrhoids by ligation of the hemorrhoidal arteries and to restore the anatomical position of the prolapsed mucosa instead of excision of the hemorrhoids ,,,.
| Methods|| |
This prospective, randomized, clinical study was carried out in Al Ahli Hospital, Qatar and Al Amiri Hospital, Kuwait, between June 2011 and June 2015. It included 126 patients with grade IV hemorrhoids, who were divided into two equal groups: group A, in which 63 patients were operated for DG-HAL with RAR; and group B, in which 63 patients were operated for MM hemorrhoidectomy. The follow-up period was 1 year.
The protocol was approved by an ethics committee. A written consent and IRB forms were obtained from all patients for the surgery after they had been explained in detail the procedures to be used in the study, and their possible complications and postoperative symptoms.
The main inclusion criteria were grade IV hemorrhoid disease and age between 20 and 70 years. Exclusion criteria were elderly individuals above 70 years, pregnancy, inflammatory bowel diseases, rectal malignancy, acute hemorrhoid episodes with thrombosis, prior hemorrhoidectomy, and intercurrent anal pathology (fistula and/or fissure). The main end point was a comparison of the two groups with respect to postoperative pain. Secondary end points included outcome in the mid-term (after 1 year).
Preoperatively, all patients underwent full clinical examination including digital rectal examination and proctoscopy, as well as complete blood count, prothrombin time, partial thromboplastin time, and international normalized ratio. All patients above 40 years underwent full colonoscopy before the operation to exclude any colonic pathology.
On the day of surgery, all patients received 2 g ceftriaxone and 500 mg metronidazole intravenously and a fleet enema was given 3 h before the operation. Both procedures were carried out under general anesthesia in the lithotomy position.
Doppler-guided hemorrhoidal artery ligation with recto-anal repair procedure
The first stage of the operation consisted of standard DG-HAL using an A.M.I. Trilogy (Austria) DGHAL-RAR proctoscope, ([Figure 1] and [Figure 2]. Then, the Doppler probe was placed around 3–5 cm above the dentate line to identify the branch of the superior rectal artery [Figure 3]. The accurate detection of the branches of the superior rectal artery was confirmed via Doppler sound. Subsequently, a figure of eight suture was conducted using vicryl 2-0 at the rectal mucosa where the artery had been identified using the proctoscope [Figure 4]. After accurate ligation had been confirmed via loss of the doppler vein signal, it was firmly ligated using a knot pusher [Figure 5].
|Figure 2 The built-in Doppler ultrasound sensor in the A.M.I. proctoscope.|
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|Figure 3 Insertion of the A.M.I. Trilogy proctoscope into the anal canal.|
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|Figure 4 Ligation of one of the branches of the superior rectal arteries.|
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The second stage, after the hemorrhoidal mass had been exposed between the proctoscope and the sleeve by rotating the proctoscope, RAR was conducted in a way that hemorrhoidal mass was sequentially sutured from the artery ligation site to 5 mm above the dentate line by using the vicryl used for artery ligation, and was firmly ligated in place on the rectal mucosa [Figure 6]. The aforementioned procedure was performed on six sites (toward 1, 3, 5, 7, 9, and 11 o’clock) starting from the lower middle of the anus and going clockwise. The surgery was completed when no more prolapsed hemorrhoid or artery signal was found.
Milligan Morgan hemorrhoidectomy procedure
Perianal infiltration with 10 ml of 0.25% bupivacaine before dissection was carried out. The hemorrhoids were retracted and dissected from the internal anal sphincter with the help of diathermy. The pedicles were transfixed using vicryl (0) ligatures, and then the dissected hemorrhoids were excised distal to the ligatures. Wounds were left open to granulate with adequate skin bridges. The three hemorrhoidal cushions at 3, 7, 11 o’clock were excised. Xylocain gel and hemostatic sponge were applied in the anal canal ([Figure 7], [Figure 8], [Figure 9]).
|Figure 7 (a) Grade IV hemorrhoids before DGHAL with RAR. (b) After DGHAL with RAR. DGHAL with RAR, Doppler-guided hemorrhoid artery ligation with recto-anal repair.|
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|Figure 9 (a) Grade IV hemorrhoids before MM hemorrhoidectomy. (b) After MM hemorrhoidectomy. MM, Milligan Morgan.|
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Data collected included patients’ demographics and the main presenting symptoms, operative time of the procedure, postoperative pain, postoperative consumption of analgesics, duration of hospital stay, duration to return to work, and postoperative complications. All the patients fulfilled the 1 year of follow-up period at intervals of 1 week, 1 month, 6 months, and 1 year.
Postoperative pain was managed according to the guidelines of the French Anesthesiology Society . Pain was assessed using a visual analog scale (VAS) in which 0 corresponds to ‘no pain’ and 10 to ‘maximum pain’. The aim was to keep the pain down to a VAS score of less than 3 at all times. Prescribed analgesics were classified using the WHO system. During the operation and immediately after patient recovery, the analgesic regimen included a systematic anti-inflammatory medication and subcutaneous morphine in case of pain. While the patient was hospitalized, analgesics were administered on the basis of the VAS score in the following way: VAS less than 3, a WHO class I analgesic (paracetamol); between 3 and 5, a WHO class II analgesic (paracetamol codeine, dextropropoxyphene–paracetamol); and a VAS greater than 5, a WHO class III analgesic (morphine administered systematically with paracetamol). If a given analgesic was having an inadequate but partial effect, an analgesic of the next class was prescribed. While hospitalized, patients were systematically administered an anti-inflammatory drug (300 mg ketoprofen per day), laxatives, and topical anesthetic cream. Patients were discharged once their pain was being effectively managed with oral analgesics.
The two different groups were compared using the χ2-test for qualitative variables and a parametric t-test to compare the means for quantitative variables. Performance and safety were evaluated using the χ2-test. The software used was SPSS, version 11.0 for Windows (SPSS Inc., Chicago, Illinois, USA).
| Results|| |
There were no significant differences between the two groups with respect to sex, weight, history, or risk factors. The mean age in the group A was higher than in the group B (51.2 vs. 44.4 years; P = 0.003). Clinical data were comparable in both groups except for the skin tags before the operation (33% in group A versus 65% in group B; P = 0.001) [Table 1].
The most common complain reported by the patients before the operation was the impression of a protruding anal mass (100%). Other problems included constipation (50%), frequent bleeding (47%), itching (37%), discharge and soiling (31%), and pain (30%) [Table 2].
The operative time was significantly longer in group A than in group B (32 ± 10.3 vs. 18 ± 9.1 min) (P > 0.001). The first defecation occurred sooner in group A than in group B (1.6 ± 1.0 vs. 2.1 ± 1.1 days) (P = 0.006). The mean hospital stay was significantly shorter in group A than in group B (P > 0.001). In addition, the return to work and normal activity was achieved significantly earlier in group A than in group B (P > 0.001) [Table 3].
|Table 3 Operative time, first defecation, hospital stay, and return to work|
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The VAS scores for pain were significantly higher in the MM hemorhoidectomy group during the hospital stay, especially during defecation (2.66 ± 2.19 in group A vs. 5.20 ± 2.24 in group B; P > 0.001). The consumption of class I analgesics during the hospital stay was higher in group B than in group A (P = 0.199), and the consumption of class II and class III analgesics were significantly higher in group B than in group A (P > 0.005) [Table 4].
There was no significant difference between the two groups in the postoperative complications and in recurrent prolapse after 1 year. Nine patients developed urine retention in the early postoperative period: one from group A and eight from group B; all of them were improved conservatively except the two cases in the group B that required urethral catheterization.
Three patients from the MM group were readmitted to the hospital within 1 week after discharge, two of them with fecal impaction, which necessitated manual evacuation under anesthesia, and one patient with fresh bleeding per rectum following an episode of constipation and passage of hard fecal matter; the bleeding was mild and improved with conservative measures and packing with hemostatic sponge without surgical intervention.
Two patients from the MM group presented with symptomatic anal stenosis during the routine follow-up in the outpatient clinic, which improved with regular anal dilatation. After 1 year, recurrent prolapse was detected in two patients (3%) of group A, and no recurrent prolapse was detected in group B (P = 0.225) [Table 5].
During the follow-up, patients’ questionnaire showed transient impairment of the anorectal functions in 12 patients (19%) in group A in the form of urgency in seven patients, flatus incontinence in two patients, tenesmus in one patients, and discrimination problems in two patients, and in 15 patients (23.8%) in group B in the form of urgency in four patients, flatus incontinence in six patients, tenesmus in two patients, and discrimination problems in three patients. These complications improved spontaneously within 6 weeks after surgery. There was no statistical significant difference between the two groups as regards any of these complications [Table 6].
| Discussion|| |
Many theories have coined the etiology of hemorrhoids, including venous varicosities, vascular hyperplasia in the hemorrhoidal vascular tissue, and mucosal prolapse of the recto-anal mucosa resulting in the elongation and kinking of the hemorrhoidal vessels . Although many surgical methods have been proposed, the ideal treatment for hemorrhoidal disease remains a subject of debate . Hundreds of studies have been published comparing the surgical treatments available for grade III and IV hemorrhoids, including open hemorrhoidectomy and transanal hemorrhoidal dearterialization (THD) . The ligation of the hemorrhoidal arteries (dearterialization) can provide a significant reduction of the arterial overflow to the hemorrhoidal vessels. Plication of redundant rectal mucosa (mucopexy) can provide repositioning of the prolapsed tissue to the anatomical site . It can be performed in the day care unit under epidural anesthesia .
Our study included 126 patients with grade IV hemorrhoids and 1 year follow-up period. De Nardi et al.  conducted a similar study on 50 patients with grade III hemorrhoids and 2 years of follow-up. Denoya et al.  conducted another similar study on 40 patients with grade III and IV hemorrhoids and 3 years of follow-up. Elshazly et al.  compared ligation anopexy with hemorrhoidectomy in 200 patients with grade II and III hemorrhoids, and 26 months of median follow-up period. LaBella et al.  evaluated THD in 108 patients with grade II, III, and IV hemorrhoids and 1 year of follow-up.
There were no significant differences between the two groups of our study with respect to sex, weight, history, or risk factors, and the common presenting symptoms of the patients before the operation were protruding anal mass, constipation, frequent bleeding, itching, discharge, and pain. This is in agreement with the results obtained in many similar studies ,,.
The operative time was significantly longer in the DG-HAL with RAR group of our study, which is in contrast to other studies proving the shorter operative time of DG-HAL with RAR than the open hemorrhoidectomy ,,. This could be due to the learning curve and our early experience with the procedure.
Patients in the DG-HAL with RAR group in our study experienced significantly less postoperative pain, significantly less consumption of class II and III analgesics in the postoperative period, and also had significantly earlier passage of stool than patients in the hemorrhoidectomy group. The same results were obtained in most of the similar studies ,.
We found that the mean hospital stay was significantly shorter for patients in the DG-HAL with RAR group and their return to work and normal activity was achieved significantly earlier than for patients in the hemorrhoidectomy group. This is in agreement with the results obtained by Denoya and colleagues , in their respective studies.
Our results showed that there was no significant difference between the two groups as regards postoperative complications and recurrent prolapse after 1 year; we had two recurrent prolapses in group A (3.2%). The same results were found in different studies evaluating DG-HAL with RAR ,,. But in their study, Kjaer et al.  found high failure rate (36%) after THD after 2 years of follow-up.
Impairment of the anorectal function in the form of urgency, tenesmus, flatus incontinence, and discrimination problems were higher in the hemorrhoidectomy group in our study but with no statistical importance, and spontaneously improved within 6 weeks after surgery. The same results were obtained by other similar studies ,.
| Conclusion|| |
DG-HAL with RAR is an effective minimal-invasive procedure with results comparable to MM hemorrhoidectomy for the treatment of grade IV hemorrhoids with fewer complications. Moreover, it is associated with less postoperative pain, shorter hospital stay, and earlier return to work. Longer periods of follow-up are needed to prove its long-term effectiveness.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Kaidar-Person O, Person B, Wexner SD. Hemorrhoidal disease: a comprehensive review. J Am Coll Surg 2007; 204: 102–117.
Lohsiriwat V. Hemorrhoids: from basic pathophysiology to clinical management. World J Gastroenterol 2012; 18: 2009–2017.
Denoya PI, Fakhoury M, Chang K, Fakhoury J, Bergamaschi R. Dearterialization with mucopexy vs haemorrhoidectomy for grade III or IV haemorrhoids: short-term results of a double-blind randomized controlled trial. Colorectal Dis 2013; 15(10): 1281–1288.
Wilkerson PM, Strbac M, Reece-Smith H, Middleton SB., Doppler-guided haemorrhoidal artery ligation: long-term outcome and patient satisfaction. Colorectal Dis 2009; 11(4): 394–400.
Avital S, Itah R, Skornick Y, Greenburg R. Outcome of stapled hemorrhoidopexy versus Doppler-guided hemorrhoidal artery ligation for grade III hemorrhoids. Tech Coloproctol 2011; 15(3): 267–271.
Bursics A, Morvay K, Kupcsulik P, Flautner L. Comparison of early and 1-year follow-up results of conventional hemorrhoidectomy and hemorrhoid artery ligation: a randomized study. Int J Colorectal Dis 2004; 19(2): 176–180.
Festen S, van Hoogstraten MJ, van Geloven AA, Gerhards MF. Treatment of grade III and IV haemorrhoidal disease with PPH or THD. A randomized trial on postoperative complications and short-term results. Int J Colorectal Dis 2009; 24(12): 1401–1405.
Giordano P, Gravante G, Sorge R, Ovens L, Nasto P. Long-term outcomes of stapled hemorrhoidopexy vs conventional hemorrhoidectomy: a meta analysis of randomized controlled trials. Arch Surg 2009; 144(3): 266–272.
Palimento D, Picchio M, Attanasio U, Lombardi A, Bambini C, Renda A. Stapled and open hemorrhoidectomy: randomized controlled trial of early results. World J Surg
2003; 27(2): 203–207.
Senagore AJ, Singer M, Abcarian H, Fleshaman J, Corman M, Wexner S, et al.
A prospective, randomized, controlled multicenter trial comparing stapled hemorrhoidopexy and Ferguson hemorrhoidectomy: perioperative and one-year results. Dis Colon Rectum 2004; 47(11): 1824–1836.
Walega P, Scheyer M, Kenig J, Herman RM, Arnold S, Nowak M, Cegielny T. Two-center experience in the treatment of hemorrhoidal disease using Doppler-guided hemorrhoidal artery ligation: functional results after 1-year follow-up. Surg Endosc 2008; 22(11): 2379–2383.
Brown S, Baraza W, Shorthouse A. Total rectal lumen obliteration after stapled haemorrhoidopexy: a cautionary tale. Tech Coloproctol 2007; 11: 357–358.
Pescatori M, Gagliardi G. Postoperative complications after procedure for prolapsed hemorrhoids (PPH) and stapled transanal rectal resection (STARR) procedures. Tech Coloproctol 2008; 12: 7–19.
Morinaga K, Hasuda K, Ikeda T. A novel therapy for internal hemorrhoids: ligation of the hemorrhoidal artery with a newly devised instrument (Moricorn) in conjunction with a Doppler flowmeter. Am J Coll Surg 1995; 90: 610–613.
Forrest NP, Mullerat J, Evans C, Middleton SB. Doppler-guided haemorrhoidal artery ligation with recto anal repair: a new technique for the treatment of symptomatic haemorrhoids. Int J Colorectal Dis 2010; 25(10): 1251–1256.
Faucheron JL, Poncet G, Voirin D, Badic B, Gangner Y. Doppler-guided hemorrhoidal artery ligation and rectoanal repair (HAL-RAR) for the treatment of grade IV hemorrhoids: longterm results in 100 consecutive patients. Dis Colon Rectum 2011; 54(2): 226–231.
Ratto C, Donisi L, Parello A, Litta F, Doglietto GB. Evaluation of transanal hemorrhoidal dearterialization as a minimally invasive therapeutic approach to hemorrhoids. Dis Colon Rectum 2010; 53(5): 803–811.
Denoya P, Tam J, Bergamaschi R. Hemorrhoidal dearterialization with mucopexy versus hemorrhoidectomy: 3-year follow-up assessment of a randomized controlled trial. Tech Coloproctol 2014; 18: 1081–1085.
Tempel MB, Pearson EG, Page M, Pollock D, Gilmore-Lynch K, Peche W, et al.
Survey of patient satisfaction after Doppler-guided transanal hemorrhoidal dearterialization performed in ambulatory settings. Tech Coloproctol 2014; 18(6): 607–610.
Delbos A. Management of post-operative pain on surgical wards. Ann Fr Anesth Réanim 1998; 17: 649–662.
Rasheed S, Razzaq S, Riaz S. Comparison of stapled versus Milligan Morgan hemorrhoidectomy in hemorrhoids surgery. J Sheikh Zayed Med Coll 2015; 6:798–801.
Kara C, Sozutek A, Yaman I, Yurekli S, Karabuga T. Ligation under vision in the management of symptomatic hemorrhoids: a preliminary experience. Asian J Surg 2015; 38(3): 121–125.
Simillis C, Thoukididou SN, Slesser AA, Rasheed S, Tan E, Tekkis PP. Systematic review and network meta-analysis comparing clinical outcomes and effectiveness of surgical treatments for hemorrhoids. Br J Surg 2015; 102(13): 1603–1618.
Ratto C. THD Doppler procedure for hemorrhoids: the surgical technique. Tech Coloproctol 2014; 18:291–298.
Ratto C, de Parades V. Doppler-guided ligation of hemorrhoidal arteries with mucopexy: a technique for the future. J Visc Surg 2015; 152:S15–S21.
De Nardi P, Capretti G, Corsaro A, Staudacher C. A prospective, randomized trial comparing the short- and long-term results of Doppler-guided transanal hemorrhoid dearterialization with mucopexy versus excision hemorrhoidectomy for grade III hemorrhoids. Dis Colon Rectum 2014; 57(3): 348–353.
Elshazly WG, Gazal AE, Madbouly K. Ligation anopexy versus hemorrhoidectomy in the treatment of second- and third-degree hemorrhoids. Tech Coloproctol 2015; 19:29–34.
LaBella GD, Main WPL, Hussain LR. Evaluation of transanal hemorrhoidal dearterialization: a single surgeon experience. Tech Coloproctol 2015; 19:153–157.
Elmer SE, Nygren JO, Lenander CE. A randomized trial of transanal hemorrhoidal dearterialization with anopexy compared with open hemorrhoidectomy in the treatment of hemorrhoids. Dis Colon Rectum 2013; 56:484–490.
Yadav V, Agrawal A, Bajpai R. A comparative study of DGHAL using RAR with open hemorrhoidectomy for treatment of grade III and IV hemorrhoids. Int J Biol Med Res 2014; 5:4047–4050.
Giordano P, Tomasi I, Pascariello A, Mills E, Elahi S. Transanal dearterialization with targeted mucopexy is effective for advanced hemorrhoids. Colorectal Dis 2014; 16(5): 373–376.
Ratto C, Parello A, Veronese E, Cudazzo E, D’Agostino E, Pagano C, et al.
Doppler-guided transanal hemorrhoidal dearterialization for hemorrhoids: results from a multicenter trial. Colorectal Dis 2014; 17:10–19.
Liu H, Yang C, Chen B, Wu J, He H. Clinical outcomes of Doppler-guided hemorrhoidal artery ligation: a meta-analysis. Int J Clin Exp Med 2015; 8(4): 4932–4939.
Kjær S, Lund HH, Schulze S, Bisgaard T. Limited success in patients treated with transanal hemorrhoidal dearterialization. Dan Med J 2014; 61(12): A4971–A4974.
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8], [Figure 9]
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6]