Home Current issue Ahead of print Search About us Editorial board Archives Submit article Instructions Subscribe Contacts Login 

 Table of Contents  
CASE REPORT
Year : 2014  |  Volume : 33  |  Issue : 4  |  Page : 277-280

Laparoscopic excision of benign multicystic peritoneal mesothelioma


Gastrointestinal Surgical Center, Department of General Surgery, Mansoura University, Mansoura, Egypt

Date of Submission18-Jul-2014
Date of Acceptance25-Aug-2014
Date of Web Publication24-Dec-2014

Correspondence Address:
Ahmed El Geidie
Gastroenterology Surgical Center, Mansoura University, Jehan St, Mansoura, Dakahlia 35516
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-1121.147620

Rights and Permissions
  Abstract 

Benign multicystic peritoneal mesothelioma is a rare disease that arises from the peritoneal mesothelium. We report on a 52-year-old woman who presented with a large abdominal multicystic mass presumed to be a pancreatic pseudocyst. Laparoscopic exploration revealed a multicystic mass with area of calcification originating from the lesser curvature of the stomach. The whole tumor was successfully excised laparoscopically. Histopathology revealed benign multicystic peritoneal mesothelioma with an area of calcification. Treatment by a minimal access approach allowed the patient to recover rapidly with a short convalescence. Our case confirms the feasibility and safety of a minimal access surgical approach to a rare pathological entity.

Keywords: abdominal cyst, abdominal mass, laparoscopy, peritoneal mesothelioma


How to cite this article:
El Geidie A, Hamed H, Shehta A. Laparoscopic excision of benign multicystic peritoneal mesothelioma. Egypt J Surg 2014;33:277-80

How to cite this URL:
El Geidie A, Hamed H, Shehta A. Laparoscopic excision of benign multicystic peritoneal mesothelioma. Egypt J Surg [serial online] 2014 [cited 2017 Aug 18];33:277-80. Available from: http://www.ejs.eg.net/text.asp?2014/33/4/277/147620


  Introduction Top


Benign multicystic peritoneal mesothelioma (BMPM) is a rare disease with annual incidence of 0.15/100 000 arising from the peritoneal mesothelium [1,2]. We report, to the best of our knowledge for the first time in the surgical literature, a case of a BMPM arising from the lesser curvature of the stomach successfully resected by laparoscopy.


  Case report Top


A 52-year-old female patient presented to us by a history of recurrent attacks of dull aching pain in the epigastrium of about 2 years duration. This pain was radiating to the back, increased by food ingestion, and was associated with nausea and vomiting. There was no history of previous surgical operations or other comorbidities. Her abdominal examination was irrelevant with no palpable masses. All laboratory results were within normal ranges. Serological markers for hydatid cyst were negative. Carcinoembryonic antigen was 3.2 ng/ml and carbohydrate antigen 19-9 was 2 U/ml. Esophagogastroduodenoscopy was ordered and showed extrinsic compression on the posterior aspect of body of the stomach, but there were no evident mucosal abnormalities. Abdominal computed tomography (CT) revealed a 7 5 cm ill-defined cystic lesion in the lesser sac containing areas of calcification. The lesion was related to anterior aspect of the pancreas with no line of separation. CT diagnosis was mostly a pancreatic pseudocyst [Figure 1].
Figure 1: Computed tomographic scan of the patient suggesting pancreatic pseudocyst.

Click here to view


The patient was submitted for laparoscopic exploration. A nasogastric tube was placed. The patient was placed in the French position with the surgeon standing between legs. Five ports were used [Figure 2]: a 10-mm port above the umbilicus (for camera), another 10-mm port at the left midclavicular line for the surgeon's right hand, and three 5-mm ports (one at the right midclavicular line for the surgeon's left hand, one at the left anterior axillary line for the assistant, and one just below the xiphisternum for liver retraction).
Figure 2: Port design.

Click here to view


Laparoscopic examination revealed a grape-like cystic lesion located beneath, but not attached to, the left liver lobe. The lesion was covered by a thin layer of the gastrohepatic ligament, which was divided using Harmonic shears (Harmonic scalpel; Ethicon Endosurgery, Cincinnati, Ohio, USA). Its relationship with the anterior surface of the pancreas was assessed and found no attachment. With gentle traction and countertraction, we could trace the origin of the lesion to be from the lesser curvature of the stomach [Figure 3]. After complete laparoscopic dissection of the lesion until reaching its origin from the stomach, a small portion of the lesser curvature of the stomach to which the lesion was attached was excised using Echelon 60 Endopath stapler (Ethicon Endosurgery). The specimen was placed in an extraction bag and extracted after extending the midline 10-mm port slightly. During surgery, we made every effort to avoid spillage of contents during dissection and manipulation to avoid recurrence. After resection we examined the lesion [Figure 4]. It was a cystic mass measuring about 15 × 10 × 5 cm, multiloculated, thin walled, containing mucin, with some areas of calcification. The patient had an uneventful recovery and she initiated oral intake the night of surgery and was discharged next morning. She was closely followed up by ultrasonography (US) and CT and remained free of symptoms and had no recurrence for 10 months after surgery.
Figure 3: After dissection, the tumor was attached by a pedicle to the lesser curve of the stomach.

Click here to view
Figure 4: Tumor after laparoscopic e xcision.

Click here to view


Microscopic examination revealed multicystic structures lined by flat to cuboidal cells; the wall is fibrous with fibrin deposition and mild inflammatory infiltrate.


  Discussion Top


BMPM, also known as multilocular peritoneal inclusion cysts, is an uncommon lesion arising from the peritoneal mesothelium that covers the serous cavity [3]. It was first identified by Mennemeyer and Smith in 1979 [4]; since then ~150 cases were reported worldwide [5]. Unlike malignant mesothelioma, it is not associated with asbestos exposure [6]. BMPM is characterized by solitary or multiple, thin-walled, multiloculated cysts filled with serous fluid or blood. Their sizes vary from few millimeters to 30 cm [7]. This lesion occurs most frequently in women during their reproductive years [8-10] and is associated with a history of previous abdominal surgery [7], endometriosis [11,12], or pelvic inflammatory disease [7].

Mostly, BMPM is asymptomatic and is often discovered incidentally during examination for other complaints. It may present with vague abdominal pain, nausea, vomiting, and constipation. When it reaches large sizes, it may present as a painful abdominal mass [1]. In addition, its presentation in the form of acute abdomen had been reported [3]. None of the common imaging techniques allow for a definitive differential diagnosis between BMPM and other similar multilocular cystic lesions. In addition, fine-needle aspiration cytology is mostly not specific, and samples show only reactive mesothelial cells. The final differential diagnosis can be obtained from surgical biopsy or through examination of complete surgical specimens [5].

Mesothelioma is a rare tumor arising from the epithelial and mesenchymal elements of the mesothelium, the cellular layer covering most internal organs. The commonest site of mesothelioma is the pleura, followed by the peritoneum and the pericardium [13]. BMPM is also a rare entity with most information coming from individual case reports. It is an intermediate-grade tumor, between benign peritoneal adenomatoid tumors and the more common malignant peritoneal mesothelioma [14].

BMPM mainly involves the pelvic peritoneum, above the Douglas pouch, the uterus, round ligament, spleen, liver, small intestine, appendix, rectum, and previous scars with rare involvement of the upper abdomen and retroperitoneum [15]. A few cases have also been described in the tunica vaginalis [16] and the spermatic cords [17]. The etiology remains unclear and there is no association with asbestos exposure, unlike malignant mesothelioma [6]. Some authors suggest that it is neoplastic, whereas others find it a reactive process. The presence of history of prior surgery, endometriosis, and inflammation suggests that it is a special form of peritoneal reaction to chronic irritation, with mesothelial cell entrapment, reactive proliferation, and cystic formation [3]. Our patient had no history of previous operations. The neoplastic origin is based on slow but progressive growth rates, tendency to recurrence, low incidence of previous abdominal infection, and a high disease-related mortality [8].

The great majority of patients being women of reproductive age suggest a role of female sex hormones in its pathogenesis [18]. BMPM appears typically as solitary or multiple, thin-walled, unilocular cysts filled with serous or mucinous fluid or blood. Their size can vary from a few millimeters to 30 cm. It may be attached or free in the peritoneal cavity. Histologically, the cysts are lined by a single layer of flat or cuboidal cells and mesothelial cells, embedded in fibrovascular stroma. Focal adenomatoid or squamous metaplasia may be seen. Mitosis and atypical cells are usually rare [7]. There have been rare reports of transformation to low-grade malignant mesothelioma, but it is generally classified as a benign process [18]. The gross and histologic findings in our cases were similar to those reported in the literature. Mesothelial cells stain positive for calretinin, thrombomodulin, and cytokeratin 5/6, and these markers allow for a differential diagnosis between BMPM and serum papillar carcinoma of the peritoneum. The cells are negative for endothelial marker CD31 [19].

The differential diagnosis of BMPM includes a variety of malignant and benign lesions that present as solitary or multicystic abdominal masses. Cystic lymphangioma (cystic hygroma), cystic adenomatoid tumor, cystic forms of endosalpingiosis, endometriosis, Mullerian cysts involving the retroperitoneum, and cystic mesonephric duct remnants are the main differential diagnosis among benign lesions. Malignant lesions include malignant mesothelioma and serous tumors of the peritoneum [20]. Multilocular cystic lymphangiomas are the most commonly confused lesions with BMPM. Cystic lymphangiomas usually occur in male children in extrapelvic regions. They are usually found localized to the small bowel, omentum, mesocolon, or retroperitoneum and contain chylous contents. Unlike BMPM, they also have mural lymphoid aggregates and smooth muscle [15].

BMPM usually presents with vague lower abdominal pain, mass, or both, but it is also commonly diagnosed incidentally upon laparotomy for other surgeries [6]. It may also present with obstructive symptoms such as nausea, bloating, or vomiting. In addition, some patients may present with an acute abdomen [3]. Women with this lesion often have a history of prior pelvic surgery, endometriosis, or pelvic inflammatory disease [21]. Physical examination may show abdominal tenderness, distention, or a palpable mass [14]. Imaging modalities that can be utilized include US, CT, or MRI. US demonstrates multiseptated anechoic cysts variable in size and number. The fluid within them is generally anechoic, but they may contain echoes from debris or hemorrhage. CT is often the most useful diagnostic tool as it provides sectional images of the abdominal and retroperitoneal compartments. CT provides information about the location and extent of the mass and demonstrates a well-defined, low-attenuation mass with occasional noncalcified septa. It gives information about relationship with nearby organs, which helps to determine feasibility of resection [22]. MRI provides additional coronal and sagittal planes. The watery serous content has low signal intensity on T1-weighted images and intermediate to high signal intensity on T2-weighted images [23].

Because of its rarity, BMPM treatment options remain an area of controversy. Currently, aggressive surgical resection is the main stay of treatment with palliative debulking and reoperation for recurrence [24]. Aggressive surgical approaches include cytoreductive surgery with peritonectomy and perioperative intraperitoneal chemotherapy to eliminate all gross and microscopic disease [21]. With high recurrence rate and its malignant potential, debulking surgery does not appear to be the most acceptable treatment option for BMPM. Patients may suffer from poorly controlled chronic abdominal and pelvic pain [24]. There is a 40-55% recurrence rate in female patients and a 33% recurrence rate in male patients [25]. Thus, routine follow-up imaging is required after operation, especially if complete enucleation could not be performed. Because of its rarity, there are no established follow-up or postoperative imaging guidelines. It is recommended to perform follow-up CT scan every 3 months for the first year after operation and then yearly for 5 years due to intraoperative spillage [13]. We followed this follow-up protocol in our patient and the patient remained free of recurrence at 1-year follow-up.

There are few reports of laparoscopic resection for BMPM [26-29], but laparoscopic excision of BMPM of the stomach has not been previously reported in the surgical literature. In our patient, the laparoscopy was undertaken with a presumed diagnosis of a pancreatic pseudocyst. Laparoscopic resection was carried out after verifying the benign nature of the lesion by absence of infiltration to adjacent organs. To ensure a complete excision, the portion of the lesser curvature of the stomach from which the lesion was attached was resected. The use of endo-GIA stapler, not sutures, facilitated this job. Cautious and judicious handling of the tumor is important at laparoscopy to avoid spillage of tumor contents, which is associated with tumor seedlings and recurrence. Laparoscopic surgery for BMPM is far adventitious to open surgery as laparoscopic excision of BMPM does not deprive the patient the benefits of minimally invasive surgery, thus allowing the patient to recover rapidly with minimal pain, and the cosmetic result was excellent.

Finally, preoperative and perioperative recognition of BMPM is difficult but essential for proper surgical management. Although ~150 cases had been described in the literature, publication of more case reports on BMPM is required to better understanding of this entity.


  Acknowledgements Top


 
  References Top

1.
Cavallaro A, Berretta M, Menzo E, et al. Cystic peritoneal mesothelioma: report of a case. Surg Today 2011; 41:141-146.  Back to cited text no. 1
    
2.
Cuartas JE, Maheshwari AV, Qadir R, et al. Benign multicystic peritoneal mesothelioma in a cesarean-section scar presenting as a fungating mass. Int J Clin Oncol 2008; 13:275-278.  Back to cited text no. 2
    
3.
Safioleas MC, Constantinos K, Michael S, et al. Benign multicystic peritoneal mesothelioma: a case report and review of the literature. World J Gastroenterol 2006; 12:5739-5742.  Back to cited text no. 3
    
4.
Mennemeyer R, Smith M Multicystic peritoneal mesothelioma: a report with electron microscopy of a case mimicking intraabdominal cystic hygroma (lymphangioma). Cancer 1979; 44:692-698.  Back to cited text no. 4
    
5.
Takemoto S, Kawano R, Honda K, et al. Benign multicystic peritoneal mesothelioma mimicking recurrence of an ovarian borderline tumor: a case report. J Med Case Rep 2012, 6:126-129.  Back to cited text no. 5
    
6.
Snyder JA, Carman R, Aggon AA, et al. Benign multicystic peritoneal mesothelioma: a rare case presenting as pneumoperitoneum and pneumotosis intestinalis. J Gastrointest Oncol 2011; 2:55-58.  Back to cited text no. 6
    
7.
Tangjitgamol S, Erlichman J, Northrup H, et al. Benign multicystic peritoneal mesothelioma: cases reports in the family with diverticulosis and literature review. Int J Gynecol Cancer 2005; 15:1101-1107.  Back to cited text no. 7
    
8.
Weiss SW, Tavassoli FA Multicystic mesothelioma. An analysis of pathologic findings and biologic behavior in 37 cases. Am J Surg Pathol 1988; 12:737-746.  Back to cited text no. 8
    
9.
O'Neil JD, Ros PR, Storm BL, et al. Cystic mesothelioma of the peritoneum. Radiology 1989; 170:333-337.  Back to cited text no. 9
    
10.
Szollosi A, Ferenc C, Pinter T, et al. Benign cystic mesothelioma, a rare tumor of the peritoneum. Magy Seb 2005; 58:35-37.  Back to cited text no. 10
    
11.
Groisman GM, Kerner H Multicystic mesothelioma with endometriosis. Acta Obstet Gynecol Scand 1992; 71:642-644.  Back to cited text no. 11
    
12.
Urbanczyk K, Skotniczny K, Kucinski J, et al. Mesothelial inclusion cysts (so-called benign cystic mesothelioma) - a clinicopathological analysis of six cases. Pol J Pathol 2005; 56:81-87.  Back to cited text no. 12
    
13.
Pitta X, Andreadis E, Ekonomou A, et al. Benign multicystic peritoneal mesothelioma: a case report. J Med Case Rep 2010; 4:385-389.  Back to cited text no. 13
    
14.
Vyas D, Pihl K, Kavuturu S, et al. Mesothelioma as a rapidly developing giant abdominal cyst. World J Surg Oncol 2012, 10:277-279.  Back to cited text no. 14
    
15.
Clement PB, Young RH In: Mills SE, Carter D, Greenson JK, Reuter VE, Stoler MH, editors. The peritoneum. Sternberg's diagnostic surgical pathology. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2009. 2395-2396.  Back to cited text no. 15
    
16.
Lane TM, Wilde M, Schofield J, et al. Benign cystic mesothelioma of the tunica vaginalis. BJU Int 1999; 84:533-534.  Back to cited text no. 16
    
17.
Tobioka H, Manabe K, Matsuoka S, et al. Multicystic mesothelioma of the spermatic cord. Histopathology 1995; 27:479-481.  Back to cited text no. 17
    
18.
Pantanowitz L, Botero M: Giant mesenteric cyst: a case report and review of the literature. Internet J Pathol 2001; 1:2.  Back to cited text no. 18
    
19.
Ohta M, Kawabata T, Yamamoto M, et al. TSU68, an antiangiogenic receptor tyrosine kinase inhibitor, induces tumor vascular normalization in a human cancer xenograft nude mouse model. Surg Today 2009; 39:1046-1053.  Back to cited text no. 19
    
20.
Rosai J In: Peritoneum, retroperitoneum, and related structures. Rosai and Ackerman's surgical pathology. Rosai J editor Edinburgh: Elsevier; 2011:2233-2270.  Back to cited text no. 20
    
21.
Uzüm N, Ozçay N, Ataoðlu O Benign multicystic peritoneal mesothelioma. Turk J Gastroenterol 2009; 20:138-141.  Back to cited text no. 21
    
22.
Alzaraa A, Mousa H, Dickens P, et al. Idiopathic benign retroperitoneal cyst: a case report. J Med Case Rep 2008; 2:43.  Back to cited text no. 22
    
23.
Levy AD, Arnáiz J, Shaw JC, et al. From the archives of the AFIP: primary peritoneal tumors: imaging features with pathologic correlation. Radiographics 2008; 28:583-607.  Back to cited text no. 23
    
24.
McCaffrey JC, Foo FJ, Dala N, et al. Benign multicystic peritoneal mesothelioma associated with hydronephrosis and colovesical fistula formation: report of a case. Tumori 2009; 95:808-810.  Back to cited text no. 24
    
25.
Allam M, Seywright M, Robins JB The uncertain problem of peritoneal bubblewrap. Br J Obstet Gynaecol 1998; 105:1332-1334.  Back to cited text no. 25
    
26.
Ricci F, Borzellino G, Ghimenton C, et al. Benign cystic mesothelioma in a male patient: surgical treatment by the laparoscopic route. Surg Laparosc Endosc 1995; 5:157-160.  Back to cited text no. 26
    
27.
Vara-Thorbeck C, Toscano-Mendez R Peritoneal cystic mesothelioma. Surg Endosc 2002; 16:220.  Back to cited text no. 27
    
28.
Pinto V, Rossi AC, Fiore MG, et al. Laparoscopic diagnosis and treatment of pelvic benign multicystic mesothelioma associated with high CA19.9 serum concentration. J Minim Invasive Gynecol. 2010; 17:252-254.  Back to cited text no. 28
    
29.
Saad S, Brockmann M, Maegele M Benign peritoneal multicystic mesothelioma diagnosed and treated by laparoscopic surgery. J Laparoendosc Adv Surg Tech A. 2007; 17:649-652.  Back to cited text no. 29
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]



 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract
Introduction
Case report
Discussion
Acknowledgements
References
Article Figures

 Article Access Statistics
    Viewed1428    
    Printed17    
    Emailed1    
    PDF Downloaded87    
    Comments [Add]    

Recommend this journal


[TAG2]
[TAG3]
[TAG4]